Nanoparticles Containing Gel Formulation for the Treatment of Psoriasis

Background: Psoriasis is a widespread chronic disease affecting 1-3% of total population and in most cases, treated by topical application corticosteroids. Though, the route very demanding because physicochemical nature diseased stratum corneum so no, single treatment works for every patient. The oral evidence harsh side effects systemic immunosuppression which can be avoided route. Objectives: objective present study to design, develop, evaluate nanoparticulate gel containing Cyclosporine A psoriasis. Methods: loaded nanoparticles were formulated modified nanoprecipitation technique characterized particle size, encapsulation efficiency, morphological analysis, drugpolymer compatibility study, powder x-ray diffraction analysis. Optimized formulation further converted into using Carbopol 934. Results: showed spherical shape with smooth surface. In vitro antiproliferative activity proved that cell viability was not affected blank nanoparticles, as there no effect concentration types surfactant on causing death. hydrates skin helps higher permeation gel. Conclusion: anti-psoriatic suggested developed exhibits improved dermal delivery also had superior growth compared free Cyclosporine. Dermal pharmacokinetic established amount reaching viable layer slightly high Thus, might potential system